How polynucleotide therapy helps thin, hollowed, or pigmented under-eyes where filler is too risky.
The under-eye area is one of the most requested treatment zones and one of the most technically difficult. The skin is thin, the anatomy is variable, and filler placed even slightly off-target can produce lumps, puffiness, or a bluish discolouration that lasts months.
Polynucleotide therapy, often called salmon DNA, has changed how we treat the under-eye. The product, highly purified polynucleotides derived from salmon DNA, is biocompatible and bioregenerative. Rather than adding volume, it stimulates fibroblast activity, improves skin quality, and supports the natural firmness of the tissue.
Where filler adds, polynucleotides repair. The under-eye becomes less crepey, less translucent, less hollow-looking, and less prone to the dark shadow that often comes from thin skin showing the vasculature beneath. Across three to four sessions, two to three weeks apart, most clients see meaningful improvement.
We use this often as a first-line treatment for clients who want a refreshed under-eye but for whom filler is not the right answer. That includes clients with thin skin, prominent vasculature, pigmentation under the eye, or fine crepiness without significant volume loss.
The session takes around 30 minutes. We use the smallest needles, multiple shallow injection points, and topical anaesthetic. Most clients describe it as mildly uncomfortable, not painful. The treated area may swell slightly for 24 hours, and tiny bruises sometimes appear at injection points but resolve within a few days.
We often combine polynucleotides with skin-quality work in the same area, gentle LED, fractional non-ablative laser if indicated, and a strict home protocol. The cumulative effect builds across the course.
If you have been told you need filler under your eyes, ask whether polynucleotides have been considered first. For many people, they are the better answer.