Salmon DNA (PDRN)
Regenerative treatment for glowing, restored skin
At a Glance
Pain Level
Minimal, topical numbing applied
Downtime
Mild swelling or bruising for 24-48 hours
Sessions
Single session per area
Duration
30-45 minutes
Results
Visible within 1-2 weeks
Frequency
Every 6-12 months depending on product
What is Salmon DNA (PDRN)?
Salmon DNA treatment, also known as polynucleotide or PDRN therapy, is an advanced regenerative skin treatment derived from purified salmon DNA fragments. It is designed to repair, regenerate, and restore skin quality at a cellular level, making it a key treatment in regenerative aesthetics.
Benefits
- Personalised to your skin and goals
- Performed by qualified practitioners
- Clinically proven technology
Is This Right for You?
Adults seeking a regenerative treatment to rebuild skin quality, elasticity, and thickness, particularly those with ageing, sun-damaged, or post-inflammatory skin damage who want cellular-level repair rather than added volume..
You may benefit if you have:
- Skin aging and loss of elasticity
- Fine lines and wrinkles
- Acne scars and skin damage
- Under-eye dark circles and thinning skin
- Dehydrated and dull skin
- Post-inflammatory skin damage
Pre-Treatment Care
- Drink 1.5-2 litres of water daily for 48 hours before
- Stop aspirin, ibuprofen, fish oil, vitamin E, and ginkgo for 5-7 days before (unless medically required)
- Arrive with clean, makeup-free skin
- If you have a cold sore history, start antiviral prophylaxis 24 hours before
- Tell us about severe fish or shellfish allergies and any autoimmune conditions
- Plan a quiet 1-2 days, mild swelling and small bumps are common
Post-Treatment Care
- Drink 2 litres of water daily for 7 days to support tissue repair
- Apply cold compresses for the first 6 hours if swelling is noticeable
- Do not touch or massage the treated area for 24 hours
- Avoid heat (saunas, hot yoga, hot showers) and alcohol for 24-48 hours
- No strenuous exercise for 24 hours
- Apply SPF 50+ once makeup resumes
- Pause retinoids and acids for 3 days
- Mild redness, small raised bumps, or bruising for 24-72 hours are normal
- Book your next session at the recommended 2-3 week interval
- Drink 2 litres of water daily for 48 hours before, well-hydrated blood gives a better PRF yield
- Eat a full meal 1-2 hours before your session (blood draw on an empty stomach can cause lightheadedness)
- Stop aspirin, ibuprofen, fish oil, vitamin E, and ginkgo for 5-7 days before (unless medically required) to reduce bruising
- Avoid alcohol for 48 hours before
- Arrive with clean, makeup-free skin (or a cleaned scalp for hair treatment)
- Wear loose, comfortable clothing with easy arm access for the blood draw
- If you have a cold sore history, start antiviral prophylaxis 24 hours before
- Tell us about any anticoagulant medications, anaemia, or low platelet counts
- Drink 2 litres of water daily for 5-7 days to support healing
- Avoid touching, rubbing, or massaging the treated area for 24 hours
- Avoid makeup for 12-24 hours on the face
- Avoid heat (saunas, hot yoga, hot showers) and alcohol for 24-48 hours
- No strenuous exercise for 24 hours
- Apply SPF 50+ once makeup resumes
- Mild redness, swelling, small raised bumps, or bruising for 24-72 hours are normal
- For scalp treatment, do not wash the scalp for 24 hours
- Pause retinoids and actives for 3 days
- Book your next session at the recommended 4-6 week interval
Frequently Asked Questions
What are polynucleotides and how do they work?
Polynucleotides (PDRN/PN) are ultra-purified DNA fragments derived from salmon, structurally compatible with human DNA. When injected, they bind to adenosine receptors on your skin cells, stimulating fibroblast activity, collagen production, tissue regeneration, and anti-inflammatory responses.
Is this the same as the Salmon DNA Eyes treatment?
Same product family, different protocol. Salmon DNA Eyes focuses on the delicate under-eye area with a dedicated micro-dose technique. General Salmon DNA treatment can cover the full face, neck, décolleté, or acne-scarred areas for broader regeneration.
Is it safe if I'm allergic to fish?
The polynucleotides are ultra-purified, proteins that cause fish allergy are removed during manufacturing. However, if you have severe anaphylactic fish allergy, we recommend discussing with your doctor. Mild fish sensitivity is generally not a contraindication.
How many sessions will I need?
A starter course of 3-4 sessions spaced 2-3 weeks apart. Results build progressively, thicker, more elastic skin, reduced inflammation, and improved texture build over the course. Maintenance every 4-6 months preserves the effect.
When will I see results?
Subtle hydration and brightening within 1 week. Meaningful skin quality improvement, elasticity, and glow builds over 4-8 weeks and peaks 2-3 months after completing the course.
How does this compare to PRP, PRF, or exosomes?
Different regenerative options with different mechanisms. PRP/PRF uses your own blood. Exosomes deliver signalling vesicles. Polynucleotides deliver direct DNA fragments that drive tissue repair. Your doctor will recommend based on your goals, skin type, and whether you prefer autologous or biologic products.
Ready to Book?
Start with a personalised consultation. Our experts will assess your skin and recommend the best approach for you.
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